ITLN1, orchestrated by the IFNγ-IRF1 axis, suppresses hepatocellular carcinoma proliferation via ERK1/2 activation
In summary, our study found that ITLN1, regulated by IFNγ-IRF1 axis, suppresses HCC proliferation by constitutively activating ERK1/2 signaling and holds promise as a prospective prognostic indicator and a plausible therapeutic target for HCC.
Authors
- Tong Yuan (ORCID: https://orcid.org/0000-0003-3211-1322)
- Haisu Tao (ORCID: https://orcid.org/0000-0002-2768-3513)
- Ronghua Zhu
- Huang Zhiyong (ORCID: https://orcid.org/0000-0002-5208-3149)
- Junjie Liu (ORCID: https://orcid.org/0000-0002-8409-4766)
- Erlei Zhang (ORCID: https://orcid.org/0000-0002-7251-0275)
- Huifang Liang (ORCID: https://orcid.org/0000-0001-6874-3634)
- Li Jiang (ORCID: https://orcid.org/0000-0003-2652-0699)
Institutions
- Zhujiang Hospital (CN)
- First Affiliated Hospital of Shihezi University Medical College (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1016/j.tranon.2025.102600
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00