Identification and validation of novel risk genes for intervertebral disc disorder by integrating large-scale multi-omics analyses and experimental studies
Collectively, this work provides an updated compendium of putative IDD risk genes and delineates pathogenic roles for TMEM190, CILP2, and FOXO3, providing a broad hint for further research on novel mechanism and therapeutic targets for IDD.
Authors
- Bingyang Dai (ORCID: https://orcid.org/0000-0002-6193-8516)
- Zhengya Zhu (ORCID: https://orcid.org/0000-0002-9250-4251)
- Yu Chen (ORCID: https://orcid.org/0000-0001-9933-8869)
- Zheng Li (ORCID: https://orcid.org/0000-0002-8837-0318)
- Zhe Zhang (ORCID: https://orcid.org/0000-0002-8036-698X)
- Cheng Dong (ORCID: https://orcid.org/0009-0001-6579-6041)
- Qianjin Wang (ORCID: https://orcid.org/0000-0001-5959-0592)
Institutions
- Hong Kong Polytechnic University (HK)
- Xuzhou Medical College (CN)
- Chinese University of Hong Kong (HK)
- Shenzhen Polytechnic University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-11-12
- DOI
- https://doi.org/10.3389/fmed.2025.1698050
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Xuzhou Medical University