Eupalinolide A inhibits cancer progression and induces ferroptosis and apoptosis by targeting the AMPK/mTOR/SCD1 signalling in non-small cell lung cancer
EA inhibited the proliferation and migration of NSCLC cells by the modulation of lipid metabolism through the activation of the ROS-AMPK-mTOR-SCD1 signalling pathway. Therefore, EA might be considered as a promising candidate in the development of therapeutics against NSCLC.
Authors
- Changxiao Hu (ORCID: https://orcid.org/0000-0002-4483-6067)
- Lin Zhao (ORCID: https://orcid.org/0000-0003-3514-4330)
- Yong Wei (ORCID: https://orcid.org/0000-0002-6824-5130)
- Lianhong Pan (ORCID: https://orcid.org/0000-0002-2788-8455)
- Fuwei Kang (ORCID: https://orcid.org/0000-0001-8216-2633)
- Feng Wang (ORCID: https://orcid.org/0000-0002-4322-2127)
- N. L. Wang (ORCID: https://orcid.org/0009-0008-8918-9044)
- Dilong Chen
- Xingbo Long (ORCID: https://orcid.org/0000-0002-5918-687X)
- Na Zhou (ORCID: https://orcid.org/0000-0003-2656-7948)
- Jiafeng Tang
- Zeyao Tang (ORCID: https://orcid.org/0000-0003-2412-5871)
- Chen Wang (ORCID: https://orcid.org/0009-0008-5773-5522)
- Yonghui Zhang
- Lei Li (ORCID: https://orcid.org/0000-0002-4758-3130)
- Jun‐Qi Zhang (ORCID: https://orcid.org/0000-0002-8585-5467)
- Xiyang Zhang (ORCID: https://orcid.org/0000-0002-8641-3281)
- Hua Yang (ORCID: https://orcid.org/0000-0002-1396-5448)
- Zhenggang Ren
Institutions
- Qianjiang Central Hospital (CN)
- Chongqing Emergency Medical Center (CN)
- Chongqing Municipal Government (CN)
- First People's Hospital of Chongqing (CN)
- Chongqing Three Gorges University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.3389/fphar.2025.1649314
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Natural Science Foundation of Chongqing
- Chongqing Municipal Education Commission