Multimodal neuroimaging of Col4a1-mutant mouse models of Gould syndrome
These findings demonstrate that high-field multimodal MRI can sensitively detect and differentiate cerebrovascular abnormalities among <i>Col4a1</i> mutant mouse models of Gould syndrome. The approach provides a powerful, noninvasive platform for assessing genotype-phenotype relationships and for identifying brain regions at heightened risk in cSVD, supporting its potential use in early diagnosis and mechanistic studies of vascular pathology.
Authors
- Douglas B. Gould (ORCID: https://orcid.org/0000-0001-5127-5328)
- Cassandre Labelle‐Dumais (ORCID: https://orcid.org/0000-0002-2134-2240)
- Myriam M. Chaumeil (ORCID: https://orcid.org/0000-0002-2110-4613)
- Xiaowei Wang (ORCID: https://orcid.org/0009-0002-9544-2073)
- Xiao Gao (ORCID: https://orcid.org/0000-0003-4042-8362)
Institutions
- University of California, San Francisco (US)
- Institute of Human Genetics (PL)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-11-12
- DOI
- https://doi.org/10.3389/fnins.2025.1639871
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Research to Prevent Blindness
- BrightFocus Foundation
- National Institutes of Health
- University of California, San Francisco
- National Eye Institute