Effect of esketamine on postoperative pain relief and depressive status in patients with traumatic fractures
Continuous postoperative infusion of esketamine (0.5-0.75 mg/kg over 24 h) in patients with traumatic lower limb fractures effectively alleviates postoperative depressive symptoms, provides opioid-sparing analgesia, reduces opioid-related adverse effects like nausea and vomiting, and is associated with increased BDNF and decreased IL-6 levels.
Authors
- Tao Zhou (ORCID: https://orcid.org/0000-0002-9782-7324)
- Mingsheng Zhang (ORCID: https://orcid.org/0000-0003-4999-925X)
- Jinhui Xu (ORCID: https://orcid.org/0009-0008-4404-5389)
- Zhongyu Liu (ORCID: https://orcid.org/0000-0001-7385-5681)
Institutions
- First Affiliated Hospital of Jiangxi Medical College (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-11-12
- DOI
- https://doi.org/10.3389/fmed.2025.1684134
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Jiangxi Province