Integrated gut microbiome and metabolomics analysis reveals microbial-metabolic cross-talk in allergic rhinitis
Our findings demonstrate that AR is associated with gut dysbiosis and metabolic dysfunction, highlighting the role of microbial-derived metabolites in immune regulation via the gut-nose axis. These insights support the potential for microbiota-targeted therapeutic strategies in AR management.
Authors
- Shengzhi Zhao (ORCID: https://orcid.org/0000-0003-1992-2067)
- Hehua Huang
- Wenchao Guan
- Dianyong Hou
- Gang Sun (ORCID: https://orcid.org/0000-0001-8594-557X)
- X. Wang (ORCID: https://orcid.org/0000-0002-6666-6820)
- Min Zhang (ORCID: https://orcid.org/0000-0001-8083-5603)
- Hong Zhang (ORCID: https://orcid.org/0000-0002-4084-5150)
- Chong Xu (ORCID: https://orcid.org/0009-0001-5861-3673)
- Ruonan Chai (ORCID: https://orcid.org/0009-0009-6422-2060)
Institutions
- General Hospital of Shenyang Military Region (CN)
- Heilongjiang Provincial Hospital (CN)
- Northeastern University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.3389/fmicb.2025.1652915
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81