Discovery and optimization of a synthetic small protein domain targeting antibodies
This study underscores the potential of small folded protein domains, such as WW domains, as versatile affinity ligands for antibodies and other molecular targets, thereby broadening their applicability in biotechnology and bioengineering.
Authors
- Ana Cecília A. Roque (ORCID: https://orcid.org/0000-0002-4586-3024)
- Cátia O. Soares
- Manuel João Brandão Matos (ORCID: https://orcid.org/0000-0001-8711-3101)
- Ana Sofia Pina (ORCID: https://orcid.org/0000-0001-9729-0371)
- Carolina M. Natal (ORCID: https://orcid.org/0000-0001-5185-9294)
- Ana Margarida Gonçalves Carvalho Dias (ORCID: https://orcid.org/0000-0001-7416-7215)
Institutions
- Unidade em Ciências Biomoleculares Aplicadas
- Universidade Nova de Lisboa (PT)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.3389/fbioe.2025.1678111
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Applied Molecular Biosciences Unit
- Fundação para a Ciência e a Tecnologia
- European Regional Development Fund