Exploring the mechanism of analgesic effect of Tuina on alleviating delayed muscle soreness in exercise-induced muscle damaged rats: a combined transcriptome- and non-targeted metabolome-based analysis
Tuina alleviates EIMD-associated pain and promotes muscle recovery by modulating inflammatory, promoting tissue repair pathways, inhibiting ferroptosis, and activating cAMP signaling, with the 48 h post-intervention mark representing a critical window for therapeutic effect.
Authors
- Yu Xia (ORCID: https://orcid.org/0000-0002-7872-7205)
- Ruichi Zhang (ORCID: https://orcid.org/0000-0002-2357-4010)
- Lunyu Li (ORCID: https://orcid.org/0000-0001-9036-3996)
- Binyu Yao (ORCID: https://orcid.org/0000-0001-7024-8085)
- Haili Ding
- Liubu Ayi
- Jiawen Liu (ORCID: https://orcid.org/0000-0002-7536-3880)
- Zhonghao Li (ORCID: https://orcid.org/0000-0001-8427-5818)
- Qingsong Liu (ORCID: https://orcid.org/0000-0002-0862-9116)
Institutions
- Guiyang Medical University (CN)
- University of Electronic Science and Technology of China (CN)
- Sichuan University (CN)
- Chengdu Sport University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-11-12
- DOI
- https://doi.org/10.3389/fmed.2025.1654141
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China