Tigecycline pharmacodynamics in the hollow fiber system of Mycobacterium avium-complex lung disease and the utility of MICs and time-kill studies in drug development
Instead of static time-kill studies with a reference strain, inclusion of multiple MAC isolates in HFS-MAC studies improves the precision of pharmacokinetic/pharmacodynamic parameter estimates. Tigecycline administered via the inhalational route could contribute to the treatment of MAC-LD.
Authors
- Shashikant Srivastava (ORCID: https://orcid.org/0000-0002-8786-8851)
- Tawanda Gumbo (ORCID: https://orcid.org/0000-0001-7592-8012)
- Devyani Deshpande (ORCID: https://orcid.org/0000-0002-1665-7619)
Institutions
- The University of Texas at Tyler (US)
- Baylor University Medical Center (US)
- 490 BioTech (United States) (US)
- Practical Action (ZW)
- The University of Texas Health Science Center at Tyler (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.3389/fphar.2025.1682477
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases