Effect of 13 traditional Chinese medicine drug preparations against Neisseria gonorrhoeae
This study represents the first report about the antibacterial activity of these 13 TCMs against <i>N. gonorrhoeae</i>. The results indicate that CR, Phellodendri Chinensis Cortex (PCC), Forsythiae Fructus (FF), Taraxaci Herba (TH), and Scutellariae Radix (SR) exhibited good antibacterial activity against <i>N. gonorrhoeae</i>, highlighting their potential as promising therapeutic options for gonococcal infections. In contrast, the MICs of Bupleuri Radix (BR), Cimicifugae Rhizoma (CFR) showed correlations with those of ceftriaxone, azithromycin, and spectinomycin, suggesting that they may be unsuitable for monotherapy of gonococcal infections, given the potential risk of cross-resistance. Nevertheless, further <i>in vitro</i> experiments and clinical studies are required to validate these observations.
Authors
- Weiyun Li
- Wenqi Xu (ORCID: https://orcid.org/0000-0001-7876-1756)
- Shao-Chun Chen (ORCID: https://orcid.org/0000-0002-6447-928X)
- Qian Zhou (ORCID: https://orcid.org/0000-0002-0712-1062)
- Yuanqin Huang
- Yue-Ping Yin (ORCID: https://orcid.org/0000-0003-1700-2750)
- Cindy Ke Zhou (ORCID: https://orcid.org/0000-0003-4814-4305)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-6041-4454)
- Xia Zhang (ORCID: https://orcid.org/0000-0003-4843-8944)
- Wenfeng Liao
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Hong Kong Baptist University (HK)
- Guizhou University (CN)
- Chinese Center For Disease Control and Prevention (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Chinese Academy of Medical Sciences Dermatology Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.3389/fphar.2025.1694041
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00