Regulatory effects of berberine on intestinal microecology in mice with ulcerative colitis
Berberine ameliorates symptoms of UC in mice by regulating gut microbiota and metabolite composition. MR analysis first establishes a unidirectional causal chain of PDGFA/lithocholate sulfate/<i>Alistipes</i>, and animal experiments confirm that blocking the PDGFA receptor reverses its therapeutic effects and aggravates inflammation and intestinal mucosal injury.
Authors
- Zonglang Lai
- Pingyu Liu (ORCID: https://orcid.org/0000-0002-0498-1235)
- Bin Zhao (ORCID: https://orcid.org/0000-0002-0383-097X)
- Na Song (ORCID: https://orcid.org/0000-0001-7793-570X)
- Jun Cheng (ORCID: https://orcid.org/0000-0002-3131-3275)
- Xinyi Xu (ORCID: https://orcid.org/0000-0001-6913-0549)
- Xiaohui Tang (ORCID: https://orcid.org/0009-0007-5183-3503)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Shanghai Medical College of Fudan University (CN)
- First People's Hospital of Chongqing (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.3389/fmicb.2025.1649947
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 0.00