Comparing Analyte Concentrations in Paired Tear Fluid and Blood Samples

This comprehensive analysis demonstrates that analyte concentrations in paired tear fluid and blood vary according to their functional categories, with cytokines and neuromodulators generally enriched in tear fluid, and antibodies and drugs more abundant in blood. Strong positive correlations between tear fluid and blood concentrations for most analytes support the potential of tear fluid analysis for monitoring systemic physiological and pathological conditions.