Prevention and Reversal of Hypertension‐Induced Coronary Microvascular Dysfunction by a Plant‐Based Diet
A PBD prevented CMD development and reversed established CMD in SHRs. Such benefits of PBD, which occurred without alleviating hypertension, were possibly due to improved endothelial function and likely improved VSMC function. These results support clinical trials to test PBDs in human CMD.
Authors
- Andrew T. Gewirtz (ORCID: https://orcid.org/0000-0002-6338-7578)
- Yanling Wang (ORCID: https://orcid.org/0000-0002-1172-1917)
- Jessica Danh (ORCID: https://orcid.org/0000-0001-7739-0287)
- Rafaela G. Feresin (ORCID: https://orcid.org/0000-0003-0649-2774)
- Vu L. Ngo (ORCID: https://orcid.org/0000-0002-9820-0443)
- Desiree Wanders (ORCID: https://orcid.org/0000-0003-2638-3954)
- J Tejada
- Puja K. Mehta (ORCID: https://orcid.org/0000-0002-5678-812X)
- Hannah Lail
- Rami Najjar (ORCID: https://orcid.org/0000-0001-5348-3008)
- Nedumangalam Hekmatyar
Institutions
- Emory Healthcare (US)
- Emory University (US)
- Georgia State University (US)
- Advanced Imaging Research (United States) (US)
- Institute of Infection and Immunity (CA)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1161/jaha.125.045515
- Citations
- 1
- Primary Topic
- Agriculture Sustainability and Environmental Impact
- Type
- article
- Field-Weighted Citation Impact
- 1.72