Nuclear Receptor Subfamily 4 Group A Member 1 Exacerbates Cardiac Remodeling by Inhibiting Mitochondrial Function Through the Peroxisome Proliferator‐Activated Receptor γ Coactivator‐1α/Nuclear Respiratory Factor 1/Transcription Factor A Mitochondria

Collectively, our findings demonstrate that NR4a1 drives pathological cardiac remodeling and heart failure progression by suppressing the PGC1α/NRF1/TFAM axis, leading to impaired mitochondrial function. Targeting NR4a1 and its interactions with PGC1α may hold promise for the development of novel therapeutic strategies for treating cardiac hypertrophy.