PFKFB2 Is Pivotal for Metabolic Flexibility and Differential Glucose Utilization
PFKFB2 is essential for fed-to-fasted changes in cardiac metabolism and plays an important regulatory role in protein O-GlcNAcylation. Its loss also affects systemic glucose homeostasis under stressed conditions.
Authors
- Atul Pranay (ORCID: https://orcid.org/0009-0006-3149-7437)
- Kenneth Michael Humphries (ORCID: https://orcid.org/0000-0002-6167-3175)
- Kylene M. Harold (ORCID: https://orcid.org/0000-0002-8421-6268)
- Satoshi Matsuzaki (ORCID: https://orcid.org/0009-0009-1846-3429)
- Jie Zhu (ORCID: https://orcid.org/0009-0006-9166-628X)
- Anna Faakye (ORCID: https://orcid.org/0009-0000-8519-4526)
Institutions
- Oklahoma Medical Research Foundation (US)
- University of Oklahoma Health Sciences Center (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1161/jaha.125.043921
- Citations
- 1
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81