ST6GAL1-mediated sialylation inhibits the antitumor immune response in colorectal cancer
Our results confirmed that ST6GAL1 decreases the sensitivity of tumor cells to IFNG. This study describes a novel mechanism by which ST6GAL1 promotes the immune escape and malignant progression of CRC.
Authors
- Jingwei Duan (ORCID: https://orcid.org/0000-0001-6551-9127)
- Quanlin Guan (ORCID: https://orcid.org/0000-0001-7728-2411)
- Zhenzhong Pan
- Yuanchao Shi (ORCID: https://orcid.org/0000-0001-5413-8177)
- Zexing Wang (ORCID: https://orcid.org/0000-0002-7371-3795)
- Yiliang Fang (ORCID: https://orcid.org/0000-0003-2414-2532)
- Bo Tang (ORCID: https://orcid.org/0000-0002-8712-7025)
- Zhihong Peng (ORCID: https://orcid.org/0000-0003-1256-8069)
Institutions
- Army Medical University (CN)
- Chongqing University (CN)
- Sichuan University (CN)
- Daping Hospital (CN)
- Xinqiao Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Beijing Friendship Hospital (CN)
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1007/s13402-025-01118-w
- Citations
- 2
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61