Redefining the Diagnostic Threshold for Breast Cancer-related Lymphedema
A normative, distribution-based threshold of 7.5% interlimb volume difference improves the identification of clinically meaningful BCRL compared with the traditional 10% cutoff. Adopting this empirically validated threshold may enhance early detection, intervention, and patient outcomes.
Authors
- Geoffrey E. Hespe (ORCID: https://orcid.org/0000-0003-1961-7484)
- Ronnie Labib Shammas (ORCID: https://orcid.org/0000-0001-5468-8646)
- Andrea Veronica Barrio (ORCID: https://orcid.org/0000-0001-6076-1133)
- Lillian A. Boe (ORCID: https://orcid.org/0000-0001-6279-9987)
- Stanley G. Rockson (ORCID: https://orcid.org/0000-0003-1253-474X)
- Michelle Coriddi (ORCID: https://orcid.org/0000-0001-5530-5862)
- B. Wagner (ORCID: https://orcid.org/0009-0004-3463-5730)
- Hidehiko Yoshimatsu (ORCID: https://orcid.org/0000-0001-5427-817X)
- Babak J. Mehrara (ORCID: https://orcid.org/0000-0001-5717-697X)
- Jonathan Rubin (ORCID: https://orcid.org/0009-0009-9413-5267)
- Jacob Levy (ORCID: https://orcid.org/0000-0003-0187-8336)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Pride Foundation (US)
- Early Manuscripts Electronic Library (US)
- Directorate-General for Interpretation (BE)
- Institute of Oriental Manuscripts (RU)
- Stanford Medicine (US)
- Institute for the Study of Learning and Expertise (US)
- Statistical Service (CY)
- Statistical Research (United States) (US)
- Stanford University (US)
Publication Details
- Journal
- Annals of Surgery
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1097/sla.0000000000006983
- Citations
- 1
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.05