Procyanidin displayed a synergistic effect with roxadustat on renal anemia in mice
The combination of procyanidin and roxadustat provides a promising therapeutic approach for renal anemia by improving erythropoiesis, kidney function, and iron metabolism while reducing adverse effects, such as thrombosis. These findings suggest that procyanidin may enhance the safety and efficacy of roxadustat in CKD-related renal anemia. Further studies are needed to optimize treatment regimens for clinical application.
Authors
- Yongting Luo (ORCID: https://orcid.org/0000-0001-7834-8742)
- Mingyang Cui (ORCID: https://orcid.org/0000-0003-1884-0641)
- Tao Jin (ORCID: https://orcid.org/0000-0002-7028-3419)
- Jiaxin Shi (ORCID: https://orcid.org/0000-0001-6842-4211)
- Wenbin Wu (ORCID: https://orcid.org/0009-0007-2290-4333)
- Junjie Luo (ORCID: https://orcid.org/0000-0002-8987-0533)
- Peng An (ORCID: https://orcid.org/0000-0002-0421-0035)
- Yujing Han
- Zihui Yang (ORCID: https://orcid.org/0000-0003-1457-5107)
- Ming-yue Sun
- Zhe Wang (ORCID: https://orcid.org/0000-0002-2619-8217)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Xiyuan Hospital (CN)
- Shanghai Jinyuan Senior High School (CN)
- China Agricultural University (CN)
- Central Academy of Fine Arts (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.3389/fphar.2025.1678846
- Primary Topic
- Erythropoietin and Anemia Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Agricultural University
- China Academy of Chinese Medical Sciences
- Higher Education Discipline Innovation Project