Targeting c-Jun orchestrates heat stroke-induced myocardial injury and reveals its biomarker potential
This study has systematically elucidated the central role of c-Jun in HS-induced myocardial injury. We have provided a novel biomarker for early diagnosis and prognostic evaluation of HS-induced myocardial injury. Additionally, we have identified ZG-10 as a potential therapeutic drug for HS-induced myocardial injury, which is a new treatment strategy for this condition.
Authors
- Xuemei Jiang (ORCID: https://orcid.org/0000-0001-6945-229X)
- Menglong Liu (ORCID: https://orcid.org/0000-0002-9861-8815)
- Fating Zhou
- Yu Ma (ORCID: https://orcid.org/0000-0003-2175-3346)
- Junyu Jiang (ORCID: https://orcid.org/0000-0003-0207-8832)
- Can Luo (ORCID: https://orcid.org/0000-0003-3654-933X)
- Hongxia Wang (ORCID: https://orcid.org/0000-0001-5082-003X)
- Yunfei Xiang (ORCID: https://orcid.org/0000-0003-3711-8312)
- Qingsong Chen (ORCID: https://orcid.org/0009-0008-1142-6329)
- Rui Huang (ORCID: https://orcid.org/0000-0002-0742-4338)
- Xie Jia (ORCID: https://orcid.org/0009-0000-3642-5586)
- Guangbin Huang
- Dingyuan Du (ORCID: https://orcid.org/0000-0003-2929-5896)
Institutions
- Zunyi Medical University (CN)
- Deyang Stomatological Hospital (CN)
- Chongqing Emergency Medical Center (CN)
- Affiliated Hospital of Zunyi Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1679750
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centre Scientifique et Technique du Bâtiment