Association between white matter microstructural and functional abnormalities and clinical characteristics in migraine without aura: a mediation analysis
This study reveals concomitant alterations in the function and microstructure of WM in the CC subregions and the FPT_L among MWoA patients. These alterations are significantly correlated with clinical characteristics and suggest that these abnormalities in functional fluctuations and WM integrity may serve as mediators between reduced network integration and disease duration in MWoA. These findings support the WM abnormality hypothesis and deepen our understanding of the pathophysiological mechanisms underlying MWoA.
Authors
- Xiangdong Luo
- Ling Zhao (ORCID: https://orcid.org/0000-0002-4017-8167)
- Yangxu Ou
- Chao-Rong Xie (ORCID: https://orcid.org/0000-0001-9644-931X)
- Xiao Wang (ORCID: https://orcid.org/0000-0002-0077-7341)
- Tong Wang (ORCID: https://orcid.org/0000-0002-9403-7167)
- Xuhong Yang (ORCID: https://orcid.org/0000-0002-0702-3075)
- Qinyi Yan
- Qixuan Fu (ORCID: https://orcid.org/0009-0009-6238-9991)
- Zhiyang Zhang (ORCID: https://orcid.org/0009-0004-4057-7098)
Institutions
- Science and Technology Department of Sichuan Province (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.3389/fneur.2025.1693789
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00