Early intervention with extracellular vesicles derived from human umbilical cord mesenchymal stem cells enhances survival and functional recovery after spinal cord injury in rats
Together, these findings demonstrate that early intralesional delivery of MSC-EVs enhances survival, modulates the inflammatory response, and promotes functional recovery after SCI, supporting further translational development of EV-based interventions for SCI.
Authors
- Zaquer Suzana Munhoz Costa‐Ferro (ORCID: https://orcid.org/0000-0002-9120-8856)
- Rachel Santana Cunha (ORCID: https://orcid.org/0000-0002-3855-1129)
- Elisama Araújo da Silva
- Erick Correia Loiola (ORCID: https://orcid.org/0000-0002-7926-795X)
- Ravena Pereira do Nascimento (ORCID: https://orcid.org/0000-0002-2915-3030)
- Bárbara Porto Cipriano
- Sílvia Lima Costa (ORCID: https://orcid.org/0000-0002-8975-3871)
- Joana Figueiredo (ORCID: https://orcid.org/0000-0002-1590-1974)
- Thaís Alves de Santana (ORCID: https://orcid.org/0000-0002-0617-1922)
- Adne Vitória Rocha de Lima
- Kátia Nunes da Silva
- Erik Aranha Rossi (ORCID: https://orcid.org/0000-0001-8540-5258)
- Bruno Solano de Freitas Souza (ORCID: https://orcid.org/0000-0003-3771-0439)
- Igor Campos da Silva (ORCID: https://orcid.org/0000-0002-0556-2972)
Institutions
- Universidade Federal da Bahia (BR)
- D’Or Institute for Research and Education (BR)
- Hospital São Rafael (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.3389/fphar.2025.1695914
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico