TEMPO‐Mediated Cross‐Dehydrogenative Coupling of Quinoxalin‐2(1 <i>H</i> )‐ones with Imidazo[1,2‐ <i>a</i> ]pyridines: Synthesis of 3‐(Imidazo[1,2‐ <i>a</i> ]pyridin‐3‐yl)quinoxalin‐2(1 <i>H</i> )‐ones
A TEMPO-mediated regioselective C(sp<sup>2</sup>)-H/C(sp<sup>2</sup>)-H cross-dehydrogenative coupling of quinoxaline-2(1H)-ones with imidazo[1,2-a]pyridines has been developed. The method afforded C3-(imidazo[1,2-a]pyridine-3-yl)quinoxaline-2(1H)-ones in good yields. Metal and photocatalyst-free conditions, broad substrate scope, scalability, and good functional group tolerance are the salient features of the developed methodology. Based on the control experiments, this reaction is believed to proceed through a radical pathway.
Authors
- Krishnan Rangan (ORCID: https://orcid.org/0000-0002-0518-8431)
- Dhananjay S. Nipate
- Anil Kumar (ORCID: https://orcid.org/0000-0003-4699-3178)
- Amol B. Gadekar
- Prakash N. Swami
Institutions
- Birla Institute of Technology and Science - Hyderabad Campus (IN)
- Birla Institute of Technology and Science, Pilani (IN)
Publication Details
- Journal
- Chemistry - An Asian Journal
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1002/asia.70423
- Primary Topic
- Synthesis and Biological Evaluation
- Type
- article
- Field-Weighted Citation Impact
- 0.00