Rab27a-mediated exosome secretion facilitates classical swine fever virus release and immune evasion
Classical swine fever, caused by the classical swine fever virus (CSFV) from the <i>Flaviviridae</i> family, is highly contagious. Exosomes, extracellular vesicles that transfer membrane components and nucleic acids, play a role in viral progression and immune evasion. This study shows that CSFV infection upregulates Rab27a, and the CSFV E0 and E2 proteins interact with Rab27a. By manipulating Rab27a expression, we found that Rab27a facilitates exosome release, which enhances CSFV spread. These findings suggest that CSFV exploits Rab27a to promote exosome-mediated release, aiding viral spread and immune evasion.
Authors
- Yanping Quan (ORCID: https://orcid.org/0000-0001-9733-9497)
- Zifeng Gong (ORCID: https://orcid.org/0000-0002-7494-9695)
- Xinxin Chen (ORCID: https://orcid.org/0000-0001-6521-5983)
- Liang Zhang (ORCID: https://orcid.org/0000-0002-0003-0299)
- Tao Wang (ORCID: https://orcid.org/0000-0002-3055-8721)
- Kangkang Guo (ORCID: https://orcid.org/0000-0001-6928-6412)
- Baohua Luo (ORCID: https://orcid.org/0000-0002-7109-7941)
- Ning Li (ORCID: https://orcid.org/0009-0003-2216-6087)
Institutions
- Lanzhou Veterinary Research Institute (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Lanzhou University (CN)
- Northwest A&F University (CN)
Publication Details
- Journal
- Journal of Virology
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1128/jvi.01488-25
- Primary Topic
- Animal Disease Management and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00