Peripheral blood gene expression stratifies rate of progression to type 1 diabetes in autoantibody-positive children in the TEDDY study
The enrichment of MHC class II-related functions and immune response pathways after seroconversion highlights immune activation in progressors, whose rate of progression could be stratified as fast or slow based on a 20-gene signature, which warrants confirmation in an independent cohort.
Authors
- Ahmed M. Mehdi (ORCID: https://orcid.org/0000-0002-9300-2341)
- Yann Abraham (ORCID: https://orcid.org/0000-0001-5600-5896)
- Jia Yi Hee (ORCID: https://orcid.org/0000-0002-5863-4458)
- Ranjeny Thomas (ORCID: https://orcid.org/0000-0002-0518-8386)
- Kim‐Anh Lê Cao (ORCID: https://orcid.org/0000-0003-3923-1116)
Institutions
- Queensland Health (AU)
- Translational Research Institute (AU)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- HighLife (France) (FR)
- Melbourne Genomics Health Alliance (AU)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-11
- DOI
- https://doi.org/10.3389/fimmu.2025.1703839
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centers for Disease Control and Prevention
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Environmental Health Sciences
- National Institute of Child Health and Human Development