What are the optimal transcranial direct current stimulation parameters and design elements to modulate corticospinal excitability? A systematic review and longitudinal meta-analysis
tDCS effects on corticospinal excitability are parameter dependent. Anodal tDCS tends to facilitate excitability, whereas cathodal tDCS tends to inhibit excitability (depending on stimulation parameters). Specific durations, intensities, electrode placements and designs will ensure effectiveness and optimise safety. Findings support a parameter-specific approach to guide tailored neuromodulation interventions to enhance motor cortex rehabilitation outcomes.
Authors
- Dana Hince (ORCID: https://orcid.org/0000-0003-3630-3356)
- Matheus D. Pinto (ORCID: https://orcid.org/0000-0002-2616-2492)
- Myles Murphy (ORCID: https://orcid.org/0000-0001-6068-1096)
- Casey Whife (ORCID: https://orcid.org/0000-0002-8961-3377)
- Ann‐Maree Vallence (ORCID: https://orcid.org/0000-0001-9190-6366)
- Maria Luciana Perez Armendariz
- Liam C. Tapsell (ORCID: https://orcid.org/0000-0002-8052-196X)
- Jack Andringa-Bate
- Shaswat Senger
Institutions
- Edith Cowan University (AU)
- Murdoch University (AU)
- The University of Western Australia (AU)
- La Trobe University (AU)
- Australian Football League (AU)
- Université Bourgogne Franche-Comté (FR)
- Avenir Health (US)
- The University of Notre Dame Australia (AU)
Publication Details
- Journal
- Neurological Research and Practice
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1186/s42466-025-00449-1
- Citations
- 1
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Raine Medical Research Foundation