De novo genome assembly of Ansell's mole-rat ( <i>Fukomys anselli</i> )

Ansell's mole-rat (Fukomys anselli) is an African rodent known for its subterranean lifestyle and unique phenotypic traits, including extreme longevity, magnetoreception, and a cooperative breeding social structure. Efforts to dissect the genetic architecture of these traits and to decipher their phylogenetic relationships within the broader African mole-rat family would greatly benefit from a reference-grade genome. Here, we report a first genome assembly of a male Ansell's mole-rat. By combining Oxford Nanopore Technologies long reads and Illumina short reads with Hi-C data, we generated a chromosome level assembly with a total length of 2.27 Gb, 412 scaffolds, and a scaffold N50 of 72.4 Mb. We identified 99.54% of expected genes and annotated 29,094 transcripts using RNA sequencing data. This high-quality de novo genome of F. anselli lays the foundation for dissecting the genetic and evolutionary basis of its extraordinary traits and resolving African mole-rat phylogeny.

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Publication Details

Journal
G3 Genes Genomes Genetics
Published
2025-11-11
DOI
https://doi.org/10.1093/g3journal/jkaf271
Primary Topic
Evolution and Paleontology Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

De novo genome assembly of Ansell's mole-rat ( Fukomys anselli )

Michaela Frye, Ângela T.F. Gonçalves, Veronica F. Busa, Raphael T. F. Coimbra et al.
G3 Genes Genomes Genetics
Evolution and Paleontology Studies
article

De novo genome assembly of Ansell's mole-rat ( Fukomys anselli )

Michaela Frye, Ângela T.F. Gonçalves, Veronica F. Busa, Raphael T. F. Coimbra, Duncan T. Odom, Mikaela Behm, Sabine Begall, Rebecca E. Wagner, Milica Bekavac
article en

Abstract

Ansell's mole-rat (Fukomys anselli) is an African rodent known for its subterranean lifestyle and unique phenotypic traits, including extreme longevity, magnetoreception, and a cooperative breeding social structure. Efforts to dissect the genetic architecture of these traits and to decipher their phylogenetic relationships within the broader African mole-rat family would greatly benefit from a reference-grade genome. Here, we report a first genome assembly of a male Ansell's mole-rat. By combining Oxford Nanopore Technologies long reads and Illumina short reads with Hi-C data, we generated a chromosome level assembly with a total length of 2.27 Gb, 412 scaffolds, and a scaffold N50 of 72.4 Mb. We identified 99.54% of expected genes and annotated 29,094 transcripts using RNA sequencing data. This high-quality de novo genome of F. anselli lays the foundation for dissecting the genetic and evolutionary basis of its extraordinary traits and resolving African mole-rat phylogeny.

G3 Genes Genomes GeneticsVol. 16(1)
German Cancer Research Center (DE), Heidelberg University (DE), University of Duisburg-Essen (DE)
Deutsches Krebsforschungszentrum
Openalex Percentile: Top 85%
Evolution and Paleontology Studies
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De novo genome assembly of Ansell's mole-rat ( <i>Fukomys anselli</i> ) — Michaela Frye, Ângela T.F. Gonçalves, et al. · G3 Genes Genomes Genetics (2025) | TGRS Research Map | TGRS