De novo genome assembly of Ansell's mole-rat ( <i>Fukomys anselli</i> )
Ansell's mole-rat (Fukomys anselli) is an African rodent known for its subterranean lifestyle and unique phenotypic traits, including extreme longevity, magnetoreception, and a cooperative breeding social structure. Efforts to dissect the genetic architecture of these traits and to decipher their phylogenetic relationships within the broader African mole-rat family would greatly benefit from a reference-grade genome. Here, we report a first genome assembly of a male Ansell's mole-rat. By combining Oxford Nanopore Technologies long reads and Illumina short reads with Hi-C data, we generated a chromosome level assembly with a total length of 2.27 Gb, 412 scaffolds, and a scaffold N50 of 72.4 Mb. We identified 99.54% of expected genes and annotated 29,094 transcripts using RNA sequencing data. This high-quality de novo genome of F. anselli lays the foundation for dissecting the genetic and evolutionary basis of its extraordinary traits and resolving African mole-rat phylogeny.
Authors
- Michaela Frye (ORCID: https://orcid.org/0000-0002-5636-6840)
- Ângela T.F. Gonçalves (ORCID: https://orcid.org/0000-0002-3890-7658)
- Veronica F. Busa (ORCID: https://orcid.org/0000-0002-3981-9975)
- Raphael T. F. Coimbra (ORCID: https://orcid.org/0000-0002-6075-7203)
- Duncan T. Odom (ORCID: https://orcid.org/0000-0001-6201-5599)
- Mikaela Behm (ORCID: https://orcid.org/0000-0002-3272-1377)
- Sabine Begall (ORCID: https://orcid.org/0000-0001-9907-6387)
- Rebecca E. Wagner (ORCID: https://orcid.org/0009-0009-3957-5016)
- Milica Bekavac (ORCID: https://orcid.org/0009-0005-1082-9204)
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- G3 Genes Genomes Genetics
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1093/g3journal/jkaf271
- Primary Topic
- Evolution and Paleontology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsches Krebsforschungszentrum