A six-year longitudinal study identifies a statin-independent association between low LDL-cholesterol and risk of type 2 diabetes
Taken together, our findings demonstrate a strong inverse association between LDL-C and incident T2D in the general population. The increased risk of T2D at lower LDL-C levels appears to be independent of statin use, supporting the role of LDL-C as a potential biomarker of T2D susceptibility.
Authors
- Roberto Piccinocchi (ORCID: https://orcid.org/0000-0001-9257-1123)
- Carmine Morisco (ORCID: https://orcid.org/0000-0002-2158-6317)
- Gaetano Santulli (ORCID: https://orcid.org/0000-0001-7231-375X)
- Bruno Trimarco
- Daniela Pacella (ORCID: https://orcid.org/0000-0003-2343-5069)
- Raffaele Izzo (ORCID: https://orcid.org/0000-0002-0308-2836)
- Maria Virginia Manzi (ORCID: https://orcid.org/0000-0002-1979-7131)
- Stefano Cristiano (ORCID: https://orcid.org/0009-0001-6096-2768)
- Stanislovas S. Jankauskas (ORCID: https://orcid.org/0000-0002-0843-5098)
- Giuseppe Giugliano (ORCID: https://orcid.org/0000-0002-1467-1687)
- Maria Lembo (ORCID: https://orcid.org/0000-0001-6454-2560)
- Gaetano Piccinocchi (ORCID: https://orcid.org/0000-0002-3095-2198)
- Paola Gallo
- Giovanni Esposito (ORCID: https://orcid.org/0000-0003-0565-7127)
- Luca Bardi
- Valentina Trimarco (ORCID: https://orcid.org/0000-0001-5869-2247)
Institutions
- Albert Einstein College of Medicine (US)
- Feinstein Institute for Medical Research (US)
- Hodges University (US)
- Federico II University Hospital (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Società Italiana di Medicina Generale (IT)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1186/s12933-025-02964-6
- Citations
- 2
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 4.01