MiR-27a-5p deficiency in plasma exosomes derived from obese individuals exacerbates ventilator-induced lung injury in vitro and in vivo
Our findings suggest that the increased susceptibility of obese patients to VILI is likely, at least in part, due to a lack of miR-27a-5p in plasma exosomes. Targeting miR-27a-5p and its associated molecules may be a promising therapeutic avenue for preventing and treating VILI in obese patients.
Authors
- Bailun Wang
- Yi Zhang (ORCID: https://orcid.org/0000-0001-7300-2590)
- Yang Li (ORCID: https://orcid.org/0000-0002-7134-5685)
- Daqing Ma (ORCID: https://orcid.org/0000-0003-1235-0537)
- Changping Gu (ORCID: https://orcid.org/0000-0003-3862-847X)
- Liang Zhao (ORCID: https://orcid.org/0000-0002-1429-0884)
- Yongtao Sun (ORCID: https://orcid.org/0000-0001-7431-8714)
- Qian Chen (ORCID: https://orcid.org/0000-0002-8918-0313)
- Yuelan Wang
Institutions
- Shandong University (CN)
- People’s Hospital of Rizhao (CN)
- Affiliated Hospital of Taishan Medical University (CN)
- Children's Hospital of Zhejiang University (CN)
- Shandong Provincial Hospital (CN)
- Chelsea and Westminster Hospital (GB)
- Shandong First Medical University (CN)
- Ningbo First Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1186/s12967-025-06988-0
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81