The biological scaling of Alzheimer’s disease neuropathological changes across primate species

The biological scaling of amyloid plaque development follows an isometric model (proportional to lifespan), whereas tau tangles emerge at a similar temporal horizon across primate species, regardless of lifespan (a chronometric model). This temporal decoupling challenges the amyloid cascade hypothesis as a universal, cross-species biological mechanism in late-onset sporadic AD. The occurrence of full-blown ADNC may depend on the phylogenetic temporal coupling of these two biological processes.