TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice
Our proof-of-concept study demonstrates the therapeutic potential of TNC-CAR-Ms in alleviating liver fibrosis and may inform the development of future therapeutic strategies for the treatment of a range of liver diseases with a fibrotic phenotype.
Authors
- Kaizhao Chen (ORCID: https://orcid.org/0000-0003-1819-2453)
- Xiaodong Ma (ORCID: https://orcid.org/0000-0002-8351-2663)
- Yanru Zhou (ORCID: https://orcid.org/0000-0002-1311-4184)
- Ziyang Lin (ORCID: https://orcid.org/0000-0001-7228-6851)
- Hongwei Cheng (ORCID: https://orcid.org/0000-0002-4251-0645)
- Shuaishuai Zhang (ORCID: https://orcid.org/0000-0002-1441-4840)
- Haoyang Wan
- Yong Huo (ORCID: https://orcid.org/0000-0002-5407-8773)
- Qi Fu
- Wei Zhang (ORCID: https://orcid.org/0000-0001-9628-8878)
- Ziqing Gao (ORCID: https://orcid.org/0000-0003-0186-7274)
- L Chen (ORCID: https://orcid.org/0000-0003-1853-4281)
Institutions
- Xiamen University (CN)
- University of Macau (MO)
- Ministry of Education (RW)
- Ministry of Education (PT)
Publication Details
- Journal
- Military Medical Research
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1186/s40779-025-00667-3
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- South China Normal University
- Zhejiang University
- Southern Medical University