Single-cell hdWGCNA identifies ICI–related–colitis key CD8 + T cells linked to immunotherapy response and prognosis in colon cancer
CIC-key-CD8 T cells are pivotal in modulating the tumour microenvironment and can significantly impact the clinical outcome of colon cancer. Their high infiltration rate correlates with poor outcomes and immunotherapy resistance. Targeting these cells may improve therapeutic strategies for cancer immune checkpoint inhibitor treatments.
Authors
- Wanwei Zheng (ORCID: https://orcid.org/0000-0002-3916-7348)
- Shuiqing Wu (ORCID: https://orcid.org/0000-0002-1203-5580)
- Shaocong Mo (ORCID: https://orcid.org/0000-0001-8556-1314)
- Jie Liu (ORCID: https://orcid.org/0000-0002-7441-2417)
- Qingquan Gong
- Wenxuan Tang (ORCID: https://orcid.org/0009-0009-6163-3411)
Institutions
- Fujian Medical University (CN)
- Fudan University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1007/s12672-025-03891-4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00