Multi-organ single-cell analysis reveals PLD4 as a biomarker and potential therapeutic target of blastic plasmacytoid dendritic cell neoplasm
This study suggested a potential clonal origin of tumor cells, and revealed the transcriptional heterogeneity among malignant cells across different tissues in BPDCN. PLD4 was identified as a specific marker of malignant cells, aiding in the diagnosis of BPDCN and showing potential as a therapeutic target.
Authors
- Yonghu Sun (ORCID: https://orcid.org/0000-0003-4553-2871)
- Yongxia Liu (ORCID: https://orcid.org/0000-0001-6125-8599)
- Xiaotong Xue (ORCID: https://orcid.org/0000-0002-2990-0745)
- Gongqi Yu (ORCID: https://orcid.org/0000-0001-7654-5232)
- Zihao Mi (ORCID: https://orcid.org/0000-0002-2912-6374)
- Furen Zhang (ORCID: https://orcid.org/0000-0002-3383-1973)
- Hao Chen (ORCID: https://orcid.org/0000-0002-8470-5467)
- Meng Wang (ORCID: https://orcid.org/0000-0002-2047-5105)
- Zhihong Liu (ORCID: https://orcid.org/0000-0001-6093-0726)
- Zhenzhen Wang (ORCID: https://orcid.org/0000-0001-5927-2471)
- Chuan Wang (ORCID: https://orcid.org/0000-0003-3079-8431)
- Shengli Chen (ORCID: https://orcid.org/0009-0004-7705-0484)
- Jianwen Wang (ORCID: https://orcid.org/0000-0003-2227-1867)
- Xu Sang (ORCID: https://orcid.org/0000-0002-0099-3511)
- Guizhi Zhou
- Xuechao Chen
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Shandong Provincial Institute of Dermatology and Venereology (CN)
- Chinese Academy of Medical Sciences Dermatology Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1186/s12935-025-04038-9
- Primary Topic
- Cutaneous lymphoproliferative disorders research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation