Effect of n-3 polyunsaturated fatty acids on the treatment of schizophrenia: an updated systematic review and meta-analysis
Omega-3 fatty acid supplementation generally has no significant benefits for treating schizophrenia and ultra-high risk group. However, subgroup findings highlight the need for future trials focusing on early-stage patients, longer supplementation, and exploring synergistic effects with adjunctive antioxidant interventions. Clinical application should remain cautious until further confirmatory evidence emerges.
Authors
- Tzu‐Rong Peng (ORCID: https://orcid.org/0000-0002-0754-5682)
- Chia‐Yu Lin (ORCID: https://orcid.org/0000-0001-9591-9260)
- Jen‐Ai Lee (ORCID: https://orcid.org/0000-0002-6080-8736)
- Pei‐Yun Tsai (ORCID: https://orcid.org/0000-0002-6088-3875)
- Ming‐Chia Lee (ORCID: https://orcid.org/0000-0002-6209-2313)
- Ping Huang (ORCID: https://orcid.org/0000-0002-1436-5639)
- Shih Ming Chen
Institutions
- Taipei Medical University Hospital (TW)
- Taipei Municipal YangMing Hospital (TW)
- Taipei Tzu Chi Hospital (TW)
- Taipei City Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1186/s12888-025-07508-6
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00