Bushenhuoxue Formula Protects Against Lumbar Facet Joint Osteoarthritis via Acting on TDP-43-Mediated Pyroptosis to Loose Caspase-11/NLRP3 Interaction
BSHXF inhibited chondrocyte pyroptosis by increasing TDP-43 to protect against FJOA via loosening the interaction of Caspase-11 and NLRP3, which may provide a fundamental basis for treating FJOA cartilage damage.
Authors
- Kai Sun (ORCID: https://orcid.org/0000-0002-2167-3066)
- Zhiqiang Luo
- Jie Yu (ORCID: https://orcid.org/0000-0001-6928-9015)
- Liguo Zhu
- Xiaolong Lu
- Wei Xu (ORCID: https://orcid.org/0000-0002-1337-0620)
- Can Zhou (ORCID: https://orcid.org/0009-0004-8835-9305)
- Biao Zhou (ORCID: https://orcid.org/0009-0002-0900-6671)
Institutions
- First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
- Wangjing Hospital of China Academy of Chinese Medical Sciences (CN)
- Xiangtan University (CN)
Publication Details
- Journal
- Rejuvenation Research
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1177/15491684251382419
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00