Schistosoma japonicum peptide SJMHE1 promotes peripheral nerve regeneration via macrophage migrasome-derived miR-26b-5p targeting the PTEN/AKT axis
Our findings reveal a novel mechanism by which SJMHE1 promotes peripheral nerve regeneration through macrophage-Schwann cell communication mediated by miRNA delivery via macrophage migrasomes. This study highlights SJMHE1 as a promising therapeutic peptide for PNI and indicates that targeting migrasome-mediated communication between macrophages and Schwann cells may represent a new therapeutic strategy for PNI.
Authors
- Wei Zhang (ORCID: https://orcid.org/0000-0001-5292-7308)
- Liyang Dong (ORCID: https://orcid.org/0000-0002-2200-784X)
- Yongbin Ma (ORCID: https://orcid.org/0000-0002-0213-194X)
- Yu Feng (ORCID: https://orcid.org/0000-0002-7162-8554)
- Tao Li (ORCID: https://orcid.org/0000-0002-9643-5185)
- Juan Wang (ORCID: https://orcid.org/0000-0003-0767-5687)
- Wenchao Zhang (ORCID: https://orcid.org/0000-0002-6815-7173)
- Kai Zhao (ORCID: https://orcid.org/0000-0003-0576-2760)
- Yue Liu (ORCID: https://orcid.org/0000-0001-8578-7436)
- Qian Wang (ORCID: https://orcid.org/0000-0002-5144-3691)
- Dan Zhou (ORCID: https://orcid.org/0000-0002-0544-2516)
- Xingwen Chen (ORCID: https://orcid.org/0009-0005-5992-8326)
- Shang Wang
Institutions
- Jiangsu University (CN)
- Zhejiang Wanli University (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Jintan People's Hospital (CN)
- Hanzhong People's Hospital (CN)
- Magna International (Canada) (CA)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1186/s12967-025-07328-y
- Primary Topic
- Echinoderm biology and ecology
- Type
- article
- Field-Weighted Citation Impact
- 0.00