Enterococcus-derived cytolysin exacerbates ischemic stroke by disrupting the blood–brain barrier via NLRP3 activation
Cytolysin aggravates ischemic stroke by compromising the BBB via NLRP3 activation and disrupting the intestinal barrier. Targeting cytolysin and NLRP3 holds promise as a therapeutic strategy for neuroprotection during ischemic stroke.
Authors
- Jiaxue Xu (ORCID: https://orcid.org/0009-0000-0815-2883)
- Wei‐Qin Zhuang (ORCID: https://orcid.org/0000-0001-9600-5225)
- Ruoting Xu (ORCID: https://orcid.org/0000-0001-6187-9790)
- Jia Li (ORCID: https://orcid.org/0000-0002-1353-7347)
- Yisi Lin
- Yanlei Zhang (ORCID: https://orcid.org/0000-0003-1536-386X)
- Meng Huang (ORCID: https://orcid.org/0000-0002-0185-3588)
- Jiani Huang (ORCID: https://orcid.org/0000-0003-3796-0737)
- Chenglong Xie (ORCID: https://orcid.org/0000-0003-3592-9058)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1186/s12974-025-03590-5
- Citations
- 2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61