Metabolic sexual dimorphism in hypothalamic Fezf1 neuron-specific BDNF knockout
Thus, the present work provides advance in the understanding of the biology of VMH Fezf1 neurons, revealing the details of its distribution and projections, and demonstrating that the expression of BDNF in these neurons is involved, according to a sexual dimorphic pattern, in the regulation of metabolic function. In addition, this is the first evidence that, in a specific hypothalamic cell population, BDNF may have a detrimental rather than positive role in the regulation of systemic metabolism.
Authors
- Lı́cio A. Velloso (ORCID: https://orcid.org/0000-0002-4806-7218)
- Fernando Valdivieso‐Rivera (ORCID: https://orcid.org/0000-0001-5044-197X)
- Carlos H. Sponton (ORCID: https://orcid.org/0000-0003-4284-8176)
- Bruna Bombassaro (ORCID: https://orcid.org/0000-0002-8670-8119)
- Ariane Maria Zanesco (ORCID: https://orcid.org/0000-0003-4842-1421)
- Ana L. Gallo-Ferraz (ORCID: https://orcid.org/0000-0003-4117-0957)
- Marcela Reymond Simoes
- Dayana Cabral-da-Silva
Institutions
- Universidade de São Paulo (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Brazilian Institute of Neuroscience and Neurotechnology (BR)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1186/s13293-025-00770-z
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo