Molecular mechanisms and genetic predisposition to osteoarthritis and osteosarcoma through Mendelian inheritance patterns

This study systematically elucidated the genetic susceptibility mechanisms of osteoarthritis and cellular heterogeneity characteristics of osteosarcoma based on Mendelian genetic principles. The findings provide important insights into understanding the genetic basis and molecular mechanisms of orthopedic diseases, laying a theoretical foundation for precision medicine and targeted therapeutic strategy development.