Lablab purpureus bioactive fractions as potent anticancer agents: an in vitro and in Silico study
This study identified LPMMF 1.5 as a bioactive fraction with significant antioxidant and anticancer activity. Picroside-1 emerged as a key compound, exhibiting strong affinity and stable interactions with cancer-relevant targets. These findings support its potential development as a plant-derived anticancer lead candidate.
Authors
- D. Rashmi
- Sheikh F. Ahmad (ORCID: https://orcid.org/0000-0002-8282-3726)
- Sarana Rose Sommano (ORCID: https://orcid.org/0000-0001-7356-2598)
- Haneen A. Al‐Mazroua (ORCID: https://orcid.org/0000-0002-5838-3468)
- Chandan Shivamallu (ORCID: https://orcid.org/0000-0002-1886-139X)
- Shashanka K. Prasad (ORCID: https://orcid.org/0000-0002-1519-5205)
- Shiva Prasad Kollur (ORCID: https://orcid.org/0000-0003-3914-3933)
- Smitha S. Bhat (ORCID: https://orcid.org/0000-0003-0569-6804)
- Matam Pradeep (ORCID: https://orcid.org/0000-0001-5843-0378)
- Sushma Jahagirdar (ORCID: https://orcid.org/0009-0006-4875-0822)
- Gamaleldin I. Harisa
Institutions
- JSS Academy of Higher Education and Research (IN)
- King Saud University (SA)
- Institute of Plant Genetics, Polish Academy of Sciences (PL)
- Chiang Mai University (TH)
- Amrita Vishwa Vidyapeetham (IN)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1007/s12672-025-03904-2
- Primary Topic
- Phytochemistry and Biological Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- JSS Academy of Higher Education and Research
- King Saud University