–A novel peptide SMIM45-107aa promotes HCC progression via MTDH pathways and its anticancer peptide derivative
We identified SMIM45-107aa, a novel peptide encoded by LINC00634, which promoted HCC progression via the MGST1-pAKT-MTDH axis. The derived peptide 5 exhibited anticancer activity, suggesting a potential therapeutic strategy for HCC.
Authors
- Guang‐Zhi Jin (ORCID: https://orcid.org/0000-0001-8961-4196)
- Xiangyang Shi (ORCID: https://orcid.org/0000-0001-6785-6645)
- Wentao Huang (ORCID: https://orcid.org/0000-0003-0843-2417)
- Mingyi Shang (ORCID: https://orcid.org/0000-0002-5241-2686)
- Yan An (ORCID: https://orcid.org/0009-0004-7089-2523)
Institutions
- Second Military Medical University (CN)
- Donghua University (CN)
- Shanghai Jiao Tong University (CN)
- Tongren Hospital (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
- State Key Laboratory for Modification of Chemical Fibers and Polymer Materials
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1186/s12967-025-07179-7
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Shanghai Jiao Tong University
- School of Medicine, Shanghai Jiao Tong University