A novel protein cPFKFB4 encoded by hsa_circ_0065394 strengthens PKM2-mediated glucose metabolic reprogramming to facilitate pancreatic cancer progression under hypoxia
cPFKFB4, a protein encoded by hypoxia-responsive circular RNA, facilitates the proliferation and metastasis of PC cells under hypoxic conditions by regulating PKM2-mediated glycolysis. Our findings not only offer fresh standpoints and valuable insights into the crosstalk between hypoxia, glucose metabolism reprogramming, and PC, but also provide a potential biomarker and therapeutic target for the treatment of PC.
Authors
- Jingyang Yin
- Xianxing Wang
- Molin Li (ORCID: https://orcid.org/0000-0001-5645-2098)
- Junxia Chen (ORCID: https://orcid.org/0000-0002-8531-7562)
- Fuming Xie
- Yuxi Long (ORCID: https://orcid.org/0000-0002-8935-5785)
- S. David Wu (ORCID: https://orcid.org/0000-0001-5949-3266)
- Hang Chen (ORCID: https://orcid.org/0000-0002-6835-5735)
- Shan Liu (ORCID: https://orcid.org/0009-0008-6981-9731)
- Lei Cai (ORCID: https://orcid.org/0000-0002-3942-1414)
- Huaizhi Wang (ORCID: https://orcid.org/0000-0002-5421-5176)
- Aining Yang
Institutions
- Chongqing University (CN)
- Hainan University (CN)
- Hainan Agricultural School (CN)
- First People's Hospital of Chongqing (CN)
- Chongqing University of Technology (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1186/s12943-025-02500-w
- Citations
- 3
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment