Advanced nitric oxide-activated calcium overload and zinc ion-amplified oxidative imbalance in ferroptosis/apoptosis
Multi-pathway disruption of intracellular adaptive defense mechanisms and metabolic reprogramming homeostasis can be achieved via NO synergistic Zn<sup>2+</sup>, offering the potential for developing highly effective combined ferroptosis and apoptosis antitumor therapies.
Authors
- Shufang Ning
- Piaoping Yang (ORCID: https://orcid.org/0000-0002-9555-1803)
- Jiaying Tang
- Lijuan Liu (ORCID: https://orcid.org/0000-0002-8326-0371)
- Hongmei Zhou (ORCID: https://orcid.org/0000-0002-4747-8381)
- Yulin Liang
- He Ding (ORCID: https://orcid.org/0000-0002-2371-5119)
- Yujia Liang
- Chen Wang (ORCID: https://orcid.org/0000-0002-2132-0869)
Institutions
- Harbin Engineering University (CN)
- Guangxi Medical University (CN)
- Tumor Hospital of Guangxi Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1186/s12951-025-03793-1
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04