Glucose-induced active lysogeny of prophage ΦSa3XN promotes Staphylococcus aureus virulence
This study illustrates a novel example of active lysogeny for Sa3int phages and elucidates a glucose-responsive CcpA pathway that regulates ΦSa3XN excision to augment S. aureus virulence, advancing our understanding of the sophisticated interactions between S. aureus and phages.
Authors
- Jing Zhou (ORCID: https://orcid.org/0000-0002-5348-1966)
- Shuguang Lu (ORCID: https://orcid.org/0000-0003-0362-8330)
- Keting Zhu (ORCID: https://orcid.org/0000-0001-8402-8913)
- Wei Huang (ORCID: https://orcid.org/0000-0002-6943-5892)
- Gang Li (ORCID: https://orcid.org/0000-0003-0621-2779)
- Yan Zhao (ORCID: https://orcid.org/0000-0002-3414-1739)
- Chao Li (ORCID: https://orcid.org/0000-0001-9196-1859)
- Ming Li (ORCID: https://orcid.org/0000-0002-2540-1738)
- Renjie Zhou
- Xing Tian (ORCID: https://orcid.org/0009-0001-0432-5705)
- Tongyu He
Institutions
- Army Medical University (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1186/s12985-025-02993-3
- Citations
- 1
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- National Natural Science Foundation of China