Influence of biophysical and biochemical cues on Plasmodium sporozoite dynamics in skin tissue

It is essential to understand how Plasmodium sporozoites sense and respond to the skin microenvironment for designing targeted interventions. Gaining deeper insight into sporozoite behavior within skin tissue-particularly the underlying signaling pathways and gene expression patterns-combined with advances in diagnostic tools and noninvasive imaging techniques targeting the initial skin-stage infection can facilitate the identification of novel therapeutic targets.