Integrated bulk and single-cell transcriptomics identifies shared and specific immune signatures in Takayasu Arteritis
Integrated bulk and single-cell transcriptomics reveal both shared and subset-specific signaling landscapes for CD4⁺ and CD8⁺ T cells in TAK. The consistent prominence of EGR1 across compartments nominates this factor as a pivotal molecular switch and attractive therapeutic target. These data furnish a mechanistic framework for precision immune modulation in large-vessel vasculitis.
Authors
- Jian Liu (ORCID: https://orcid.org/0000-0003-3101-7553)
- Yi Yang (ORCID: https://orcid.org/0000-0002-5808-0109)
- Na Gao (ORCID: https://orcid.org/0000-0002-1831-8354)
- Kang Xu (ORCID: https://orcid.org/0000-0002-6946-8635)
- Longfei Wang (ORCID: https://orcid.org/0000-0002-3951-0783)
- Junming Zhu (ORCID: https://orcid.org/0000-0002-6919-9164)
- Yaxin Zhang (ORCID: https://orcid.org/0000-0002-3901-3613)
- Taotao Li (ORCID: https://orcid.org/0000-0002-2815-3856)
- Honglei Zhao
- Lili Pan (ORCID: https://orcid.org/0000-0003-2914-078X)
Institutions
- Aerospace Center Hospital (CN)
- Beijing Anzhen Hospital (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1186/s13075-025-03673-x
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China