Multi-omics integration reveals hypoxia-driven mechanisms in vascular dementia: a machine learning and single-cell sequencing approach
This study identified <i>DUSP1, MAFF</i>, and <i>TGFBI</i> as key players in hypoxia-related mechanisms in VaD, highlighting their pivotal roles in metabolic regulation, cell death pathways, immune microenvironment modulation, and neural differentiation. These insights enhance our understanding of VaD pathogenesis and suggest that these genes may be potential therapeutic targets for cognitive impairment.
Authors
- Hongxia Yang (ORCID: https://orcid.org/0000-0002-2293-8812)
- Zhenyu Xuan (ORCID: https://orcid.org/0000-0001-9344-8493)
- Weiwei Shan (ORCID: https://orcid.org/0009-0008-0581-6160)
- Ming‐Hsia Hu (ORCID: https://orcid.org/0000-0003-0904-255X)
- Xian Wu
- Lining Duan
Institutions
- Heilongjiang University of Chinese Medicine (CN)
- First Affiliated Hospital of Heilongjiang University of Chinese Medicine (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Annals of Medicine and Surgery
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1097/ms9.0000000000004296
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00