The relationship between serum eosinophil peroxidase and major basic protein levels in relation to severity and response to H1 antihistamines in chronic spontaneous Urticaria
Serum EPO and MBP levels are neither biomarkers predicting CSU severity nor factors predicting response to antihistamine in the severe group. This lack of association may help explain why treatments targeting eosinophil proliferation and chemotaxis have not been successful in clinical trials for patients with antihistamine-refractory CSU.
Authors
- My Huyen Le (ORCID: https://orcid.org/0000-0001-5831-1483)
- Minh Nguyet Vu (ORCID: https://orcid.org/0000-0001-5025-0209)
- Le Huu Doanh (ORCID: https://orcid.org/0000-0002-9982-9905)
- Phạm Thị Làn (ORCID: https://orcid.org/0000-0002-0127-9328)
- Nguyễn Thị Kim Cúc (ORCID: https://orcid.org/0009-0000-1203-4601)
Institutions
- Hanoi Medical University (VN)
- Vietnam National Children's Hospital (VN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1371/journal.pone.0336118
- Primary Topic
- Urticaria and Related Conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00