Tetraspanin 13 Enhances Immune Evasion in Breast Cancer by Promoting MHC-I Degradation
TSPAN13 decreases MHC-I surface expression and CD8+ T-cell activation to induce an immunosuppressive state in breast cancer, supporting targeting TSPAN13 as an immunotherapeutic strategy.
Authors
- Yutong Liu (ORCID: https://orcid.org/0009-0006-2205-2962)
- Ruge Cao (ORCID: https://orcid.org/0009-0001-7180-5004)
- Yifan Fu (ORCID: https://orcid.org/0009-0002-1696-9556)
- Dong Song (ORCID: https://orcid.org/0000-0003-2676-8803)
- Xin Guan (ORCID: https://orcid.org/0000-0002-2232-0465)
- Yuheng Wu (ORCID: https://orcid.org/0009-0002-0377-360X)
- Shiqi Yin (ORCID: https://orcid.org/0009-0000-8381-5245)
- Qian Zhao (ORCID: https://orcid.org/0009-0006-5804-6871)
- Dan Huang (ORCID: https://orcid.org/0009-0006-8944-1372)
- Ye Du (ORCID: https://orcid.org/0009-0009-7888-4102)
- Xue Wang (ORCID: https://orcid.org/0009-0002-1823-4086)
Institutions
- Anhui University of Science and Technology (CN)
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1158/0008-5472.can-25-1223
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00