Zervimesine, a Small Sigma-2 Receptor Selective Modulator for Alzheimer’s Disease
Zervimesine is a small molecule, able to cross the blood-brain barrier, readily available by straightforward organic chemistry processes, showing few "off-target" effects, but displays a potent and selective S2R modulator profile. Evidence suggests Zervimesine can protect synapses and neurons by preventing the toxic effects of soluble Aβ oligomers.
Authors
- Isabel Iriepa (ORCID: https://orcid.org/0000-0003-3475-9624)
- Carmen Abate (ORCID: https://orcid.org/0000-0001-9292-884X)
- Jose Luis Marco-Contelles (ORCID: https://orcid.org/0000-0003-0690-0328)
- Marialessandra Contino (ORCID: https://orcid.org/0000-0002-0713-3151)
Institutions
- Universidad de Alcalá (ES)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- Instituto de Química Orgánica General (ES)
- University of Bari Aldo Moro (IT)
Publication Details
- Journal
- ACS Medicinal Chemistry Letters
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1021/acsmedchemlett.5c00653
- Citations
- 1
- Primary Topic
- Pharmacological Receptor Mechanisms and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.81