miR-432 Exacerbates Obesity-Induced Dysregulation of Glucose and Lipid Homeostasis
miR-432 overexpression in adipose tissue, liver, and skeletal muscle exacerbates high-fat diet-induced disruption of metabolic homeostasis. miR-432 impairs glucose homeostasis by suppressing the PIK3R3/AKT pathway and disrupts lipid homeostasis via inhibition of the PIK3R3/PPAR-α axis or directly suppressing PPAR-α. Obesity-induced elevation of miR-432 is predominantly localized in adipocytes and driven by the CDK5/PPAR-γ axis. Adipocyte-derived exosomal miR-432 mediates systemic metabolic dysfunction, establishing an intertissue regulatory network.
Authors
- C. Sun (ORCID: https://orcid.org/0009-0005-4469-7748)
- Cuizhe Wang (ORCID: https://orcid.org/0000-0002-3338-9732)
- Maodi Liang (ORCID: https://orcid.org/0009-0004-2100-6628)
- Meixiu Zhang (ORCID: https://orcid.org/0000-0002-4308-1088)
- Xiaolong Chu
- Jingzhou Wang (ORCID: https://orcid.org/0000-0001-8142-2202)
- Jun Zhang (ORCID: https://orcid.org/0000-0001-9796-994X)
- Jianxin Xie (ORCID: https://orcid.org/0000-0002-2667-5300)
- Yanting Hou
- Congyi Wang
Institutions
- Shihezi University (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Diabetes
- Published
- 2025-11-11
- DOI
- https://doi.org/10.2337/db25-0295
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Xinjiang Production and Construction Corps